Nucleotide regulation of vasoactive intestinal peptide binding to bovine thyroid plasma membranes.
نویسندگان
چکیده
The specific binding of vasoactive intestinal peptide (VIP) to bovine thyroid plasma membranes is inhibited by guanine nucleotides. Guanosine 5'-triphosphate (GTP) and the non-hydrolyzable GTP analogs guanosine 5'-beta,gamma-imidotriphosphate (Gpp(NH)p) and guanosine 5'-O-(3-thiotriphosphate) (GTP-gamma-S) inhibited markedly the binding of VIP to its receptors. This inhibition was higher with GTP than with Gpp(NH)p and GTP-gamma-S and was due to an increase of the rate of dissociation of peptide bound to membranes. Other nucleotides did not show any effect.
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ورودعنوان ژورنال:
- Bioscience reports
دوره 10 6 شماره
صفحات -
تاریخ انتشار 1990